COSMETIC
HRIPT TEST
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COSMETIC
HRIPT TEST
REQUEST MORE INFORMATION
Assessment of
sensitisation potential
Three-phase study with
dermatological supervision
Support for skin
compatibility claims
WHAT IS AN HRIPT?
The HRIPT is an advanced study designed to assess the sensitisation potential of a product, as well as its overall skin compatibility profile following repeated exposure. Its design reproduces intense and prolonged exposure, greater than that occurring under normal conditions of use, making it possible to identify responses that would not become apparent in shorter-duration tests.
During the induction phase, the product is applied repeatedly under occlusion for several weeks in order to maximise skin exposure. This is followed by a rest phase that allows the skin to recover before the challenge phase, in which the product is reapplied to a different area to assess the possible development of an allergic response.
This approach makes it possible to distinguish between irritation mechanisms and sensitisation processes, providing a comprehensive assessment of how the product behaves on the skin and a solid basis for supporting its dermatological profile. Depending on the study objectives, volunteer selection may include different skin profiles, such as normal, sensitive, reactive, atopic or acne-prone skin, enabling an assessment tailored to the product’s target population.
WHY CARRY OUT AN HRIPT?
Sensitisation potential
Assesses whether the product may induce an allergic response following repeated exposure.
Skin compatibility
Enables the product to be classified in terms of irritation and skin compatibility.
Hypoallergenicity
Provides technical support for assessing the hypoallergenicity of the formulation.
Enhanced safety assessment
Identifies skin responses that do not become apparent in short-duration tests.
Confidence
Strengthens the product’s dermatological profile for consumers and distributors.
HOW IS THE TEST CARRIED OUT?
Protocol definition
The study design is established according to the product characteristics, its intended use and the assessment objectives.
Induction phase
The product is applied repeatedly under occlusion for several weeks in order to maximise skin exposure.
Rest phase
Application is discontinued for a defined period to allow the skin to recover before the challenge phase.
Challenge phase
The product is reapplied to a different area to assess the possible development of an allergic response.
Assessment and technical report
The results undergo dermatological assessment and a report is issued with the study conclusions.
Why choose AITEX for your HRIPT studies?
RIGOROUS, SPECIALISED DERMATOLOGICAL ASSESSMENT
The HRIPT is a prolonged study requiring strict control of each phase and precise dermatological interpretation of the results. At AITEX, the test is conducted under specialist supervision, ensuring the correct execution of the induction, rest and challenge phases.
This methodology makes it possible to clearly distinguish between irritant responses and sensitisation processes, providing a reliable assessment of the formulation’s actual behaviour on the skin.
COMPREHENSIVE CLASSIFICATION OF THE DERMATOLOGICAL PROFILE
Beyond determining whether a product has sensitising potential, the HRIPT provides an overall assessment of the formulation’s skin profile.
The study provides information to determine whether the product has irritant potential, establish its degree of skin compatibility and assess its level of hypoallergenicity according to its capacity to induce sensitisation. This information is particularly relevant for products intended for sensitive skin, children’s cosmetics and dermocosmetics.
EXPERIENCE AND COMPREHENSIVE SERVICES FOR THE COSMETICS INDUSTRY
AITEX supports cosmetic manufacturers and brands throughout the product safety assessment process. The HRIPT can be combined with other skin tolerance, safety, efficacy and microbiological control studies, creating a comprehensive strategy tailored to each formulation and target market.
This comprehensive approach enables studies to be planned in stages, progressing from initial compatibility tests to more demanding dermatological validation.
FAQS ABOUT HRIPT
What is an HRIPT?
It is an advanced dermatological study that assesses the sensitisation potential of a cosmetic product and its skin compatibility following repeated exposure.
What is the difference between an HRIPT and a Patch Test?
The Patch Test primarily assesses skin tolerance through a single exposure under occlusion. The HRIPT includes induction, rest and challenge phases, also allowing sensitisation potential to be assessed.
What phases does the test comprise?
It comprises an induction phase with repeated applications under occlusion, a rest phase that allows the skin to recover, and a challenge phase in which the product is reapplied to a different area.
What information does the study provide to the manufacturer?
It makes it possible to determine whether the product has irritant potential, establish its degree of skin compatibility and assess its level of hypoallergenicity according to its capacity to induce sensitisation.
Can the test distinguish irritation from sensitisation?
Yes. The study design makes it possible to distinguish between irritation mechanisms and sensitisation processes, providing a more comprehensive interpretation of the product’s behaviour.
Is a Patch Test mandatory?
The need for the test depends on the type of product and the safety assessment strategy defined for its market launch.
Can it support dermatological claims?
Yes. The results provide technical support for substantiating the product’s dermatological profile and skin compatibility.
For which products is it particularly recommended?
For formulations intended for sensitive skin, children’s cosmetics, dermocosmetics and products requiring particularly robust dermatological support.
Can it be combined with other safety tests?
Yes. The HRIPT can be integrated into a staged strategy alongside other skin tolerance and compatibility studies.
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INFORMATION
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